Start Submission

Reading: The Short-Term Outcome and Risk Factors Associated with the Outcome of Severe Covid-19 Disea...

Download

A- A+
Alt. Display

Original Research Papers

The Short-Term Outcome and Risk Factors Associated with the Outcome of Severe Covid-19 Disease – Retrospective Evaluation of Single-Centre Experiences from the Second Covid-19 Wave in Sri Lanka

Authors:

I. Kodikara ,

University of Ruhuna, Galle, 80000, LK
About I.
Department of Anatomy, Faculty of Medicine
X close

B. A. Galabada,

Base Hospital Homagama, Homagama, 10200, LK
About B. A.
Department of Radiology
X close

H. M. A. S. Dissanayake,

Base Hospital Homagama, Homagama, 10200, LK
About H. M. A. S.
Department of Radiology
X close

E. M. Narangoda

Base Hospital Homagama, Homagama, 10200, LK
About E. M.
Department of Radiology
X close

Abstract

Background: Prognostic data related to the Covid-19 is lacking for Sri Lankans, and for high-risk cohorts worldwide.

 

Objectives: To describe the short-term outcomes and risk factors related to severe and fatal Covid-19 disease in a high-risk symptomatic cohort with coexisting disease conditions.

 

Methods: The single-center retrospective study assessed 300 symptomatic Covid-19 infected adults admitted to Base-Hospital Homagama, Sri Lanka, from December 2020 to February 2021.

 

Results: The patients mean age (SD) was 58 (15) years, with 47% of them being men. At least one comorbidity was present in 84.3%, hypertension in 57.1% and diabetes in 53.8%. Overall, 24.3% had severe disease, 18.3% succumbed and 14.3% were managed in an ICU. Severe disease was more common among males (60.3%) than females (39.7%). Case severity (diabetes: χ2 = 4.838; p = 0.028; CKD: χ2 = 9.459; p = 0.002) and case fatality (diabetes: χ2 = 4.838; p = 0.028); CKD: χ2 = 9.459; p = 0.002) had a significant association with co-existing diabetes or chronic kidney disease (CKD). Predictors for severe disease include male gender (OR:2.292; 95%CI:1.228–4.279), low oxygen saturation (OR:2.436; 95%CI:1.304–4.552), and presence of comorbidity (OR:4.886; 95%CI:1.352–17.652). Predictors of the fatal disease include low oxygen saturation (OR:4.182; 95%CI:1.971–8.872) and the presence of comorbidity (OR:9.352; 95%CI:1.160–75.371).

 

Conclusion: Covid-19 infected adults who are having coexisting non-communicable diseases are more vulnerable to getting severe and fatal infections. And knowledge of vulnerable groups will help in developing new strategies to mitigate the effects of this pandemic.
How to Cite: Kodikara, I., Galabada, B.A., Dissanayake, H.M.A.S. and Narangoda, E.M., 2022. The Short-Term Outcome and Risk Factors Associated with the Outcome of Severe Covid-19 Disease – Retrospective Evaluation of Single-Centre Experiences from the Second Covid-19 Wave in Sri Lanka. Sri Lanka Journal of Medicine, 31(2), pp.24–34. DOI: http://doi.org/10.4038/sljm.v31i2.343
0
Views
0
Downloads
Published on 31 Dec 2022.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus