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Hypereosinophilic Syndrome: A Case of Diagnostic and Therapeutic Difficulty

Authors:

B. D. Alahakoon ,

National Hospital, LK
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B. Gowrishankar,

National Hospital, LK
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N. Weerasooriya,

National Hospital, LK
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H. Karunathilaka,

National Hospital, LK
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A. Jayanaga

National Hospital, LK
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Abstract

Hypereosinophilic syndrome (HES) is a condition with a diverse clinical presentation and prognosis. Due to its rarity, it is often under-recognized. We present a 48-year-old female patient who presented with eosinophilic pneumonia and bullous pemphigoid; a rare skin manifestation of HES. It was considered as primary HES after a comprehensive evaluation excluded secondary causes. However, clinical picture and laboratory makers were inconclusive to categorize her as either myeloid or lymphoid HES. It was presumed to be of Lymphoid HES subtype since she responded well to a course of cyclosporin A. Due to heterogeneous clinical picture and multiple molecular and laboratory markers, evaluation of a patient with eosinophilia may be challenging, time consuming and costly. Expanding knowledge of disease endotyping and novel biomarkers have favorably modified the diagnosis and management of HES.
How to Cite: Alahakoon, B.D., Gowrishankar, B., Weerasooriya, N., Karunathilaka, H. and Jayanaga, A., 2022. Hypereosinophilic Syndrome: A Case of Diagnostic and Therapeutic Difficulty. Sri Lanka Journal of Medicine, 31(2), pp.92–96. DOI: http://doi.org/10.4038/sljm.v31i2.327
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Published on 31 Dec 2022.
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