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A case of thrombotic microangiopathy and acute demyelinating central nervous system lesions as the first manifestation of systemic lupus erythematosus

Authors:

K. D. Ellepola ,

National Hospital, Kandy, LK
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R. A. Higgoda,

National Hospital, Kandy, LK
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I. K. Jayasinghe,

National Hospital, Kandy, LK
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D. R. Chamara,

National Hospital, Kandy, LK
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B. G. Premaratne,

National Hospital, Kandy, LK
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W. Dissanayake

National Hospital, Kandy, LK
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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with a relapsing and remitting course and multi- organ involvement which can present with a wide range of neuropsychiatric manifestations. Acute disseminating encephalomyelitis (ADEM) is an autoimmune demyelinating disorder of the central nervous system (CNS). Thrombotic thrombocytopenic purpura (TTP) is a medical emergency which manifests with microangiopathic haemolytic anaemia (MAHA), thrombocytopenia and neurological abnormalities and is known to be a rare association of SLE. We report a case of a 14 year old female who presented with fever and altered consciousness, subsequently diagnosed to have SLE with thrombotic microangiopathy and acute demyelinating CNS lesions in an ADEM-distribution
How to Cite: Ellepola, K.D., Higgoda, R.A., Jayasinghe, I.K., Chamara, D.R., Premaratne, B.G. and Dissanayake, W., 2021. A case of thrombotic microangiopathy and acute demyelinating central nervous system lesions as the first manifestation of systemic lupus erythematosus. Sri Lanka Journal of Medicine, 30(1), pp.109–112. DOI: http://doi.org/10.4038/sljm.v30i1.247
Published on 01 Jul 2021.
Peer Reviewed

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