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Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency

Authors:

R. Arujun ,

Teaching Hospital Jaffna, LK
About R.
University Medical Unit
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T. Kumanan,

Teaching Hospital Jaffna, LK
About T.
University Medical Unit
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V. Sujanitha,

Teaching Hospital Jaffna, LK
About V.
University Medical Unit
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T. Sooriyakumar,

Teaching Hospital Jaffna, LK
About T.
Department of Haematology
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R. M. U. K. B. Ratnayake,

Teaching Hospital Jaffna, LK
About R. M. U. K. B.
Department of Haematology
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A. Anuruththan

Teaching Hospital Jaffna, LK
About A.
Department of Haematology
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Abstract

Glucose 6 phosphate dehydrogenase (G6PD) is a housekeeping enzyme critical in the redox metabolism. In red blood cells, it is the only source of Nicotinamide adenine dinucleotide phosphate hydrogen(NADPH) that act directly and via glutathione defends these cells against oxidative stress. Dengue infection as like other infections can trigger intravascular haemolysis in G6PD deficiency patients. We have reported a 17 year old boy with G6PD deficiency presented with dengue fever which was complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis.
How to Cite: Arujun, R., Kumanan, T., Sujanitha, V., Sooriyakumar, T., Ratnayake, R.M.U.K.B. and Anuruththan, A., 2019. Dengue complicated by acute haemolysis, methaemoglobinemia, hepatitis and rhabdomyolysis in a patient with G6PD deficiency. Sri Lanka Journal of Medicine, 28(2), pp.75–80. DOI: http://doi.org/10.4038/sljm.v28i2.127
Published on 31 Dec 2019.
Peer Reviewed

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